Miss You Already begins with some brief narration over a collage of photographs—each one of Jess (Drew Barrymore) and Milly (Toni Collette) smiling or laughing or getting into some kind of trouble. In a wonderful line that describes the essence of their friendship—as well as many friendships in general—Jess says, “There weren’t many photos of me that she wasn’t in.” But when she adds an ominous, “Until now,” it becomes a line that encapsulates the movie. These two women have been friends since Jess moved to London from America as a young girl, and will be until one of them is out of the picture.
And, as we find out quickly enough, it’s Milly whose image is fading. While Barrymore’s Jess has spent her adult life focusing on her low-paying but emotionally rewarding career in some kind of NGO-centric career and living on a houseboat with her her adoring, blue collar husband—Milly has taken a more typical (and lucrative) route. She’s married to a handsome former rocker and successful businessman played by the always welcome Dominic Cooper, has two beautiful kids, and a high-powered career in PR. But she can’t have it all forever.
After the diagnosis of a malignant lump in her breast, we watch Milly struggle to accept the bad news (she so rarely gets any), and decide how to tell her husband, children, and Jess. She’ll need chemotherapy, that much is for certain, but what if it gets worse? No matter. She takes it one day at a time, making the most of a bad situation by bringing Jess along to her chemo treatments, going wig hunting with her loving—if oblivious—TV star mother (Jaccqueline Bisset), and continuing to work as though nothing’s wrong.